PARTIAL DISTAL DUODENECTOMY IN PATIENT WITH ADENOCARCINOMA.

BACKGROUND: Duodenal adenocarcinoma is a small percentage of gastrointestinal neoplasms, around 0.5%, and its treatment is based on resection of the tumor, classically by pancreaticoduodenectomy. In recent years, however, segmental resections of duodenal lesions, that do not involve the second portion or the periampullary region, have gained relevance with good surgical and oncological outcomes as well as the benefit of avoiding surgeries that can result in high morbidity and mortality. AIMS: To report a case of an elderly female patient with malignant neoplastic lesion in the third and fourth duodenal portion, non-obstructive, submitted to surgical treatment. METHODS: The technical option was the resection of the distal duodenum and proximal jejunum with preservation of the pancreas and reconstruction with side-to-side duodenojejunal anastomosis. RESULTS: The evolution was satisfactory and the surgical margins were free of neoplasia. CONCLUSIONS: Segmental resections of the duodenum are feasible and safe, offering the benefit of preventing complications of pancreaticoduodenectomies.

Application and effectiveness of Methylobacterium symbioticum as a biological inoculant in maize and strawberry crops.

The effectiveness of Methylobacterium symbioticum in maize and strawberry plants was measured under different doses of nitrogen fertilisation. The biostimulant effect of the bacteria was observed in maize and strawberry plants treated with the biological inoculant under different doses of nitrogen fertiliser compared to untreated plants (control). It was found that bacteria allowed a 50 and 25% decrease in the amount of nitrogen applied in maize and strawberry crops, respectively, and the photosynthetic capacity increased compared with the control plant under all nutritional conditions. A decrease in nitrate reductase activity in inoculated maize plants indicated that the bacteria affects the metabolism of the plant. In addition, inoculated strawberry plants grown with a 25% reduction in nitrogen had a higher concentration of nitrogen in leaves than control plants under optimal nutritional conditions. Again, this indicates that Methylobacterium symbioticum provide an additional supply of nitrogen.

Partial distal duodenectomy in patient with adenocarcinoma / Duodenectomia distal parcial em paciente com adenocarcinoma

ABSTRACT BACKGROUND: Duodenal adenocarcinoma is a small percentage of gastrointestinal neoplasms, around 0.5%, and its treatment is based on resection of the tumor, classically by pancreaticoduodenectomy. In recent years, however, segmental resections of duodenal lesions, that do not involve the second portion or the periampullary region, have gained relevance with good surgical and oncological outcomes as well as the benefit of avoiding surgeries that can result in high morbidity and mortality. AIMS: To report a case of an elderly female patient with malignant neoplastic lesion in the third and fourth duodenal portion, non-obstructive, submitted to surgical treatment. METHODS: The technical option was the resection of the distal duodenum and proximal jejunum with preservation of the pancreas and reconstruction with side-to-side duodenojejunal anastomosis. RESULTS: The evolution was satisfactory and the surgical margins were free of neoplasia. CONCLUSIONS: Segmental resections of the duodenum are feasible and safe, offering the benefit of preventing complications of pancreaticoduodenectomies.

RESUMO RACIONAL: O adenocarcinoma duodenal é uma pequena porcentagem das neoplasias gastrointestinais, em torno de 0,5%, e seu tratamento baseia-se na ressecção da massa tumoral, classicamente por pancreatoduodenectomia. Nos últimos anos, porém, as ressecções segmentares de lesões duodenais que não envolvem a segunda porção ou a região periampular têm ganhado relevância com bons resultados cirúrgicos e oncológicos e com o benefício de evitar uma cirurgia que pode apresentar alta morbimortalidade. OBJETIVOS: Reportar o caso de uma paciente feminina, idosa, com lesão neoplásica maligna na terceira e quarta porção duodenal, não obstrutiva, submetida a tratamento cirúrgico. MÉTODOS: A opção técnica foi a ressecção do duodeno distal e jejuno proximal com preservação do pâncreas e reconstrução com anastomose duodenojejunal látero-lateral. RESULTADOS: A evolução foi satisfatória e as margens cirúrgicas foram livres de neoplasia. CONCLUSÕES: As ressecções segmentares do duodeno são factíveis e seguras, com os benefícios de evitar as complicações das pancreatoduodenectomias.

Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloid angiopathy.

Introduction: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid-ß (Aß) in brain vessels and is a main cause of lobar intracerebral hemorrhage (ICH) in the elderly. CAA is associated with magnetic resonance imaging (MRI) markers of small vessel disease (SVD). Since Aß is also accumulated in Alzheimer's disease (AD) in the brain parenchyma, we aimed to study if several single nucleotide polymorphisms (SNPs) previously associated with AD were also associated with CAA pathology. Furthermore, we also studied the influence of APOE and CLU genetic variants in apolipoprotein E (ApoE) and clusterin/apolipoprotein J (ApoJ) circulating levels and their distribution among lipoproteins. Methods: The study was carried out in a multicentric cohort of 126 patients with lobar ICH and clinical suspicion of CAA. Results: We observed several SNPs associated with CAA neuroimaging MRI markers [cortical superficial siderosis (cSS), enlarged perivascular spaces in the centrum semiovale (CSO-EPVS), lobar cerebral microbleeds (CMB), white matter hyperintensities (WMH), corticosubcortical atrophy and CAA-SVD burden score]. Concretely, ABCA7 (rs3764650), CLU (rs9331896 and rs933188), EPHA1 (rs11767557), and TREML2 (rs3747742) were significantly associated with a CAA-SVD burden score. Regarding circulating levels of apolipoproteins, protective AD SNPs of CLU [rs11136000 (T) and rs9331896 (C)] were significantly associated with higher HDL ApoJ content in the lobar ICH cohort. APOEε2 carriers presented higher plasma and LDL-associated ApoE levels whereas APOEε4 carriers presented lower plasma ApoE levels. Additionally, we observed that lower circulating ApoJ and ApoE levels were significantly associated with CAA-related MRI markers. More specifically, lower LDL-associated ApoJ and plasma and HDL-associated ApoE levels were significantly associated with CSO-EPVS, lower ApoJ content in HDL with brain atrophy and lower ApoE content in LDL with the extent of cSS. Discussion: This study reinforces the relevance of lipid metabolism in CAA and cerebrovascular functionality. We propose that ApoJ and ApoE distribution among lipoproteins may be associated with pathological features related to CAA with higher ApoE and ApoJ levels in HDL possibly enhancing atheroprotective, antioxidative, and anti-inflammatory responses in cerebral ß-amyloidosis.

Estudio de caso: Adulto Mayor sedentario en contexto de pandemia a través de teleenfermería / Case study: Sedentary older adults inthe context of pandemic through telenursing

Debido a la pandemia por COVID-19, la población se vio confinada bajo estrictos reglamentos y controles sanitarios con el objetivo de disminuir los contagios, esto evocado sobre todo a los grupos etarios de riesgo, principalmente adultos mayores. El encierro, y las pocas posibilidades de que la pandemia cese, trajo consecuencias relacionadas con diferentes aristas, sobre todo las relacionadas con su salud. La nula posibilidad de presencialidad para los pacientes en relación a sus controles periódicos, contribuyeron a empeorar su situación de salud física, psicológica y mental, por lo tanto se tuvieron que implementar nuevas estrategias para poder atender a los pacientes, para así brindar cuidados atingentes y de calidad. Una de estas estrategias corresponde a la tele-enfermería, la cual tiene enfoques de promoción, prevención y educación en salud. El presente trabajo utilizó esta estrategia para la atención de un adulto mayor perteneciente al programa Vínculos, para la posterior valoración de enfermería, identificación y priorización de problemas. Considerando el contexto de pandemia, el problema de salud principal que se abordará es el sedentarismo, el cual es un factor de riesgo para enfermedades cardiovasculares y un indicador de calidad de vida. Por esto se trabajó para contribuir con respecto a la reflexión sobre el aporte del proceso de teleenfermería y el desarrollo de habilidades blandas, para crear nuevas estrategias alternativas que se puedan implementar para realizar cuidados integrales pertinentes en adultos mayores en el contexto COVID-19 actual[AU]

Introduction: Low back pain is a common occupational disease in Due to the COVID-19 pandemic, the population was confined under strict regulations and sanitary controls with the objective of reducing contagion, especially among at-risk age groups, mainly the elderly. The confinement, and the few possibilities that the pandemic would cease, brought consequences related to different aspects, especially those related to their health. The lack of possibility for patients to be present for their periodic check-ups contributed to worsen their physical, psychological and mental health situation, so new strategies had to be implemented to attend patients, in order to provide attentive and quality care. One of these strategies corresponds to tele-nursing, which focuses on health promotion, prevention and education. The present study used this strategy for the care of an older adult belonging to the Vínculos program, for the subsequent nursing assessment, identification and prioritization of problems. Considering the pandemic context, the main health problem to be addressed is sedentary lifestyle, which is a risk factor for cardiovascular diseases and an indicator of quality of life. For this reason, we worked to contribute to the reflection on the contribution of the tele-nursing process and the development of soft skills, to create new alternative strategies that can be implemented to perform relevant comprehensive care in older adults in the current COVID-19 context[AU]

Devido à pandemia da COVID-19, a população foi confinada sob regulamentos rigorosos e controlos sanitários com o objectivo de reduzir o contágio, especialmente entre os grupos etários de risco, principalmente os idosos. O confinamento, e as poucas possibilidades de que a pandemia cessasse, trouxe consequências relacionadas com diferentes aspectos, especialmente os relacionados com a sua saúde. A falta de possibilidade de os pacientes estarem presentes para os seus controlos regulares contribuiu para piorar a sua situação física, psicológica e mental, pelo que foi necessário implementar novas estratégias para poder atender os pacientes, a fim de proporcionar cuidados atenciosos e de qualidade. Uma destas estratégias é a tele-educação, que se centra na promoção, prevenção e educação para a saúde. Este estudo utilizou esta estratégia para o cuidado de um adulto mais velho pertencente ao programa Vínculos, para a subsequente avaliação, identificação e atribuição Considerando o contexto pandémico, o principal problema de saúde a abordar é o sedentarismo, que é um factor de risco para as doenças cardiovasculares e um indicador da qualidade de vida. É por isso que trabalhámos para contribuir para a reflexão sobre a contribuição do processo de tele-nursão e o desenvolvimento de competências transversais, a fim de criar novas estratégias alternativas que possam ser implementadas para realizar cuidados abrangentes relevantes para adultos mais velhos no actual contexto da COVID-19 [AU]

Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage.

Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.

Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease.

Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aß) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aß can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.

Características clínicas de la sepsis en niños internados en el Departamento de Pediatría del Hospital Nacional de Itauguá en el período 2017 al 2018 / Clinical characteristics of sepsis in children hospitalized in the pediatric department of the Hospital Nacional de Itauguá in the period 2017-2018

Introducción: La sepsis en el paciente pediátrico es una de las principales causas de morbilidad y mortalidad a nivel mundial y constituye un problema de salud pública en el país. El diagnóstico precoz y el consiguiente tratamiento oportuno disminuyen las complicaciones, la estancia hospitalaria, el consumo de recursos y mejora el pronóstico final del paciente. Objetivo: Determinar las características clínicas y epidemiológicas de la sepsis en niños internados en el Departamento de Pediatría del Hospital Nacional de Itauguá en el período 2017-2018. Métodos: Estudio retrospectivo, observacional y descriptivo de corte transverso con componente analítico. Resultados: Fueron incluidas 101 pacientes, con predominio del sexo masculino en 63,37% y el grupo lactante en 62,38%. El 88,12% obtuvo puntuación q-SOFA ≥2. La manifestación clínica que predominó en lactantes fue la hipotensión, Tas <100mmgh 88,89%, mientras que a edades mayores prevaleció la leucocitosis, en preescolares 90,00% y en escolares 94,44%. El 90,48% de los lactantes sufrieron de shock séptico y el 72,22 % SDOM. El 100 % de los preescolares cursó con shock séptico y el 40% con SDOM. En escolares, el 83,33% presentaron shock séptico y 39,68% SDOM. El 95,65% de los pacientes con SDOM presentaron falla respiratoria, el 91,30% presentaron falla cardiovascular, y el 34,78% déficit neurológico. El promedio de internación fue de 14 días. La localización del foco infeccioso fue respiratoria, en el 40,59% de los casos. El mayor porcentaje de óbitos se registró en lactantes en 30,16%. Conclusiones: Se encontró que la población más susceptible son lactantes con foco primario pulmonar. La manifestación clínica encontrada en la mayor parte de los casos fue la leucocitosis y la hipotensión. Se demostró asociación entre puntuación q-SOFA y el shock séptico. La mortalidad fue alta, probablemente debido a las elevadas cifras de shock séptico y SDOM.

Introduction: Sepsis in the pediatric patient is one of the main causes of morbidity and mortality worldwide and constitutes a public health problem in the country. Early diagnosis and subsequent timely treatment reduce complications, decreased length of inpatient stay, reductions in resource consumption and improve prognosis. Objective: Identify the clinical and epidemiological characteristics of sepsis in children interned in Department of Pediatrics at Itauguá National Hospital in the period 2017-2018. Methods: A retrospective, observational and descriptive cross-sectional study with analytical component. Results: 101 files were included. Of the patients studied, male sex prevailed in 63.37% and the nursing group in 62.38%. 88.12% scored q-SOFA ≥2. The clinical manifestation that prevailed in infants was hypotension, TAS <100mmgh 88.89%, while at older ages leukocytosis prevailed, in preschool children 90.00% and in schoolchildren 94.44%. 90.48% of infants suffered from septic shock and 72.22% SDOM. 100% of preschoolers attended with septic shock and 40% with SDOM. In schoolchildren, 83.33% presented septic shock and 39.68% SDOM. 95.65% of patients with SDOM had respiratory failure, 91.30% had cardiovascular failure, and 34.78% neurological deficit. The average hospitalization was 14 days. The location of the infectious focus was respiratory, in 40.59% of the cases. The highest percentage of deaths was recorded in infants at 30.16%. Conclusion: It was found that the most susceptible population is infants with primary pulmonary focus. The clinical manifestation found in most cases is hypotension and leukocytosis. An association between q-SOFA score and septic shock was demonstrated. Mortality was significant, probably due to the high numbers of septic shock and SDOM.

Selective aphasia and focal hypoperfusion in a bilingual patient with HaNDL syndrome.

The syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) is a rare disease (1) characterized by a benign, self-limited headache syndrome accompanied by neurological deficits (isolated aphasia can be seen in nearly 22% of these patients (2)). Differential diagnosis between acute ischemic stroke and HaNDL syndrome has to be made in order to decide whether to perform a lumbar puncture or start reperfusion treatment early. CT perfusion have proved to be useful for differential diagnosis (3). We present a case of a HaNDL patient referred to the Emergency Department as a stroke in the context of acute onset of selective aphasia (Spanish) in a bilingual patient (French-Spanish). Urgent CT perfusion during the episode revealed increased mean transit time (MTT) with normal Cerebral Blood Flow (CBF) in posterior language areas. The case provides information on a HaNDL attack and its pathophysiology with hemodynamic changes in the acute period during the episode and the benign condition of the illness.

Anatomía topográfica del nervio laríngeo superior: importancia quirúrgica en las tiroidectomías / Topographic anatomy of the upper laryngeal nerve: surgical importance in thyroidectomies

En las cirugías sobre la glándula tiroides se ha prestado mucha atención al manejo del nervio laríngeo inferior y de las glándulas paratiroides, no así del ramo lateral del nervio laríngeo superior, el cual es satélite del pedículo vascular superior de la glándula tiroides. El manejo del polo superior de la glándula tiroides requiere de un conocimiento acabado de su anatomía topográfica del área y está determinada por sus relaciones más importantes, dadas por el citado nervio y la arteria tiroidea superior principalmente. En este trabajo se pretende estudiar estas relaciones en base a la disección meticulosa del triángulo laringo-esternotiroideo ("Triángulo de Joll") de 25 cadáveres adultos formolizados. Como hallazgo relevante se informa que los "nervios en riesgo", según la clasificación de Cernea, que se basa en una distancia menor a un centímetro en el entrecruzamiento del nervio con la arteria tiroidea superior con respecto al polo superior de la glándula tiroides, es del 52 % para el lado derecho y 44 % para el lado izquierdo del cuello. El origen bajo de la arteria a nivel de la bifurcación carotídea se presenta asociada a un mayor número de "nervios en riesgo" en el lado izquierdo. Según el punto de penetración del ramo lateral del nervio laríngeo superior en el músculo constrictor inferior de la faringe se establece la clasificación de Friedman, muy útil sobre todo en cirugías ayudadas por la neuroestimulación. En esta clasifiacción los "nervios en riesgo" son aquellos que transcurrren superficial al músculo, mientras que los "nervios protegidos" serían aquellos que perforan el músculo en su porción superior. En este trabajo los "nervios en riesgo" se presentaron del lado izquierdo en el 56 % de los casos y del derecho en el 60 %, mientras que los "nervios protegidos" en el 24 % y 16 %, respectivamente.

In surgeries on the thyroid gland, much attention has been given to the management of the inferior laryngeal nerve and parathyroid glands, but not the external branch of the given by the aforementioned nerve and the superior thyroid artery. This paper intends to study these relationships based on the meticulous dissection of the larynx-sternothyroid triangle ("Joll triangle") of 25 formolized adult corpses. As a relevant finding, it is reported that the " nerves at risk" according to the Cernea classification, which is based on the distance less than one centimeter at the intersection of the nerve with the superior thyroid artery with respect to the upper pole of the gland, is 52 % for the right side and 44 % for the left side of the neck. The low origin of the artery at the level of the carotid bifurcation is associated with a greater number of "nerves at risk" on the left side. According to the penetration point of the external branch of the superior laryngeal nerve in the inferior pharyngeal constrictor muscle, the Friedman classification is established, very useful especially in surgeries aided by neurostimulation. In this classification the "nerves at risk" are those that run superficially to the muscle, while the protected nerves would be those that pierce the muscle in its upper part. In tis work, the "nerves at risk" presented on the left side in 56 % of the cases and the right side in 60 %, while those "protected" in 24 % and 16 % respectively.

Exogenous strigolactones impact metabolic profiles and phosphate starvation signalling in roots.

Strigolactones (SLs) are important ex-planta signalling molecules in the rhizosphere, promoting the association with beneficial microorganisms, but also affecting plant interactions with harmful organisms. They are also plant hormones in-planta, acting as modulators of plant responses under nutrient-deficient conditions, mainly phosphate (Pi) starvation. In the present work, we investigate the potential role of SLs as regulators of early Pi starvation signalling in plants. A short-term pulse of the synthetic SL analogue 2'-epi-GR24 promoted SL accumulation and the expression of Pi starvation markers in tomato and wheat under Pi deprivation. 2'-epi-GR24 application also increased SL production and the expression of Pi starvation markers under normal Pi conditions, being its effect dependent on the endogenous SL levels. Remarkably, 2'-epi-GR24 also impacted the root metabolic profile under these conditions, promoting the levels of metabolites associated to plant responses to Pi limitation, thus partially mimicking the pattern observed under Pi deprivation. The results suggest an endogenous role for SLs as Pi starvation signals. In agreement with this idea, SL-deficient plants were less sensitive to this stress. Based on the results, we propose that SLs may act as early modulators of plant responses to P starvation.

Lipoma arborescens en la articulación de la rodilla / Lipoma arborescens in the articulation of the knee

La Lipomatosis Sinovial es una entidad poco frecuente de la membrana sinovial, afecta con mayor frecuencia a la articulación de la rodilla, pudiendo presentarse en otras articulaciones. Ocurre en varones de la 5° o 6° década de la vida, de presentación monoarticular habitual. Su etiología es desconocida, pero se apoya un proceso reactivo más que neoplásico. Esta enfermedad tiene una morfología radiológica, macroscópica y microscópica característicamente arborescente, por infiltración adiposa del tejido subsinovial, que es clave para su diagnóstico. Presentamos el caso de un varón de 63 años, realizándose revisión de los hallazgos radiológicos y patológicos, así como su diagnóstico diferencial con otras entidades y su tratamiento.

Synovial Lipomatosis is a rare entity of the synovial membrane, most often affects the knee joint, and can occur in other joints. It occurs in 5th or 6th decade of life, men of usual monoarticular presentation. Its etiology is unknown and there is more a reactive process rather than neoplastic. This disease has a characteristically arborescent radiological, macroscopic and microscopic morphology, due to adipose infiltration of the subsinovial tissue, which is key for its diagnosis. We present the case of a 63-year-old male, reviewing the radiological and pathological findings, as well as its differential diagnosis with other entities and their treatment.

Evaluación de la Calidad vs precio de comprimidos de Metformina de 850mg de producción nacional e importados, comercializados en Paraguay utilizados para el control de diabetes / Quality vs. price evaluation of national and imported 850 mg metformin tablets marketed for the control of diabetes in Paraguay

La metformina es un fármaco de primera elección, solo o combinado, en el tratamiento inicial de pacientes con diabetes tipo 2, cuya prevalencia a nivel nacional es de 8,0% en hombres y 8,3% en mujeres, con un gasto anual de 283 USD/persona. El estudio fue realizado con el objetivo de evaluar la calidad fisicoquímica y precio de comprimidos de 850 mg de metformina comercializados en nuestro país. Se analizaron medicamentos de producción nacional e importada, conteniendo 850 mg de metformina HCl, tomando como referencia la Farmacopea de los Estados Unidos (USP 38). Para evaluar la calidad de los productos se realizaron ensayos físicos químicos, además de los perfiles de disolución según el medio propuesto por la USP 38. Los resultados obtenidos se encontraron dentro de las especificaciones de valoración, entre 96% y 101% de metformina y los perfiles de disolución entre 70% y 90% de la cantidad declarada en 20 minutos, con una eficiencia de disolución (EF) entre 58% y 93%, mostrando que no existe diferencia estadísticamente significativa (p=0,41). La variación de precios encontrados fue entre 3,6 USD y 8,4 USD. Los productos analizados pueden ser intercambiables en cuanto a la calidad y los perfiles de disolución in vitro, siendo una herramienta para demostrar intercambiabilidad de productos farmacéuticos, buscando el precio más accesible en el mercado nacional y facilitando el tratamiento adecuado sobre todo para la población de escasos recursos manteniendo la calidad y eficacia del mismo(AU)

Quality of Chronic Anticoagulation Control in Patients with Intracranial Haemorrhage due to Vitamin K Antagonists.

INTRODUCTION: Patients treated with vitamin K antagonists (VKA) are at increased risk of intracranial haemorrhage (ICH). The purpose of our study was to determine the quality of previous anticoagulation control in patients with VKA-associated ICH. MATERIALS AND METHODS: We prospectively assessed every consecutive patient admitted to our stroke unit with VKA-associated ICH between 2013 and 2016. Demographic, clinical, and radiological variables, as well as consecutive international normalized ratios (INR) during 7 previous months, were extracted. Time in therapeutic range (TTR), time over range (TOR), time below range (TBR), and percentage of INR within range (PINRR) were calculated. RESULTS AND DISCUSSION: The study population comprised 53 patients. Mean age was 79 years; 42% were women. Forty-eight patients had atrial fibrillation (AF) and 5 mechanical prosthetic valves. Therapeutic or infratherapeutic INR on arrival was detected in 64.4% of patients (95% CI 2.7 to 3.2). TTR was 67.8% (95% CI: 60.2 to 75.6 %) and PINRR was 75% (95% CI: 49.9-100). TOR was 17.2% (95% CI: 10.4 to 23.9% ) and TBR was 17% (95% CI: 10.6 to 23.9%). CONCLUSION: VKA-associated ICH happens usually in the context of good chronic anticoagulation control. Newer risk assessment methods are required.

Anticoagulación tras una hemorragia cerebral / Anticoagulation after intracerebral haemorrhage

La fibrilación auricular es responsable del 50% de los ictus de origen cardioembólico y del 20% de todos los ictus. Los ictus producidos por fibrilación auricular son más graves, discapacitantes y mortales. Los anticoa-gulantes orales tipo antivitamina K son capaces de prevenir un 64% la incidencia de ictus, a costa de incrementar el riesgo de una hemorragia intracraneal. Los anticoagulantes de acción directa tienen un 50% menos de riesgo de producir una hemorragia intracraneal que los antivitamina K. El número de pacientes anticoagulados ha aumentado considerablemente en la última década y, por consiguiente, también el de hemorragia intracraneal por anticoagulantes. Aunque su morbimortalidad es muy elevada, en los pacientes que sobreviven y están en riesgo de ictus se debe plantear si reiniciar o no la anticoagulación. Los datos existentes hasta la fecha provienen de estudios observacionales, y con ellos las guías clínicas han establecido unas recomendaciones generales con bajos niveles de evidencia, en los que recomiendan evitar la anti-coagulación en hemorragias intracraneales lobares e individualizarlo en hemorragias intracraneales profundas. A la espera de nueva evidencia científica sobre cuál puede ser la mejor estrategia preventiva, se debe individualizar la decisión en cada paciente en función de ciertos factores como son la edad, la locali-zación y etiología de la hemorragia intracraneal, qué anticoagulante produjo la hemorragia intracraneal, antecedentes de embolias previas o la presencia o no de microhemorragias cerebrales múltiples. Las opciones terapéuticas pasarían preferentemente por la utilización de los anticoagulantes de acción directa o por el cierre percutáneo de la orejuela izquierda

Atrial fibrillation causes 50% of cardioembolic strokes and 20% of all strokes. Strokes produced by atrial fibrillation are larger, more disabling and more often fatal. Antivitamin K antagonists are able to prevent 64% of strokes, but increase the risk of intracranial haemorrhage. Direct oral anticoagulants have a 50% lower risk of producing intracranial haemorrhage than vitamin K antagonists. The number of patients receiving anticoagulation has increased markedly in the last decade and, consequently, so has the risk of anticoagulant-associated intracranial haemorrhage. Although the associated morbidity and mortality are very high, the need to resume anticoagulation must be considered among survivors at risk of stroke. Currently available data are drawn from observational studies. Based on these studies, the clinical practice guidelines have established general recommendations with low levels of evidence, which include avoiding anticoagulation in lobar intracranial haemorrhages and individualisation of anticoagulation in deep intracranial haemorrhages. Until new scientific evidence is available on the most effective preventive strategy, decisions should be individualised in each patient depending on certain factors such as age, the localisation and cause of the intracranial haemorrhage, the anticoagulant that produced the cerebral bleed, prior embolisms, and the presence or absence of multiple cerebral microhemorrhages. The treatments of choice are direct oral anticoagulants or percutaneous closure of the left atrial appendage

Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics.

BACKGROUND: Nonagenarians are under-represented in thrombolytic trials for acute ischemic stroke (AIS). The effectiveness of intravenous thrombolytics in nonagenarians in terms of safety and outcome is not well established. MATERIALS AND METHODS: We used a multinational registry to identify patients aged 90 years or older with good baseline functional status who presented with AIS. Differences in outcomes-disability level at 90 days, frequency of symptomatic intracerebral hemorrhage (sICH), and mortality-between patients who did and did not receive thrombolytics were assessed using multivariable logistic regression, adjusted for prespecified prognostic factors. Coarsened exact matching (CEM) was utilized before evaluating outcome by balancing both groups in the sensitivity analysis. RESULTS: We identified 227 previously independent nonagenarians with AIS; 122 received intravenous thrombolytics and 105 did not. In the unmatched cohort, ordinal analysis showed a significant treatment effect (adjusted common odds ratio [OR]: .61, 95% confidence interval [CI]: .39-.96). There was an absolute difference of 8.1% in the rate of excellent outcome in favor of thrombolysis (17.4% versus 9.3%; adjusted ratio: .30, 95% CI: .12-.77). Rates of sICH and in-hospital mortality were not different. Similarly, in the matched cohort, CEM analysis showed a shift in the primary outcome distribution in favor of thrombolysis (adjusted common OR: .45, 95% CI: .26-.76). CONCLUSIONS: Nonagenarians treated with thrombolytics showed lower stroke-related disability at 90 days than those not treated, without significant difference in sICH and in-hospital mortality rates. These observations cannot exclude a residual confounding effect, but provide evidence that thrombolytics should not be withheld from nonagenarians because of age alone.

Mechanical thrombectomy in orally anticoagulated patients with acute ischemic stroke.

BACKGROUND AND PURPOSE: To investigate the efficacy and safety of mechanical thrombectomy in patients with acute ischemic stroke according to the oral anticoagulation medication taken at the time of stroke onset. MATERIALS AND METHODS: A retrospective multicenter study of prospectively collected data based on data from the registry the Madrid Stroke Network was performed. We included consecutive patients with acute ischemic stroke treated with mechanical thrombectomy and compared the frequency of intracranial hemorrhage and the modified Rankin Scale (mRS) score at 3 months according to anticoagulation status. RESULTS: The study population comprised 502 patients, of whom 389 (77.5%) were not anticoagulated, 104 (20.7%) were taking vitamin K antagonists, and 9 (1.8%) were taking direct oral anticoagulants. Intravenous thrombolysis had been performed in 59.8% and 15.0% of non-anticoagulated and anticoagulated patients, respectively. Rates of intracranial hemorrhage after treatment were similar between non-anticoagulated and anticoagulated patients, as were rates of recanalization. After 3 months of follow-up, the mRS score was ≤2 in 56.3% and 55.7% of non-anticoagulated and anticoagulated patients, respectively (P=NS). Mortality rates were similar in the two groups (13.1%and12.4%, respectively). Among anticoagulated patients, no differences were found for intracranial bleeding, mRS score, or mortality rates between patients taking vitamin K antagonists and those taking direct oral anticoagulants. CONCLUSIONS: Mechanical thrombectomy is feasible in anticoagulated patients with acute ischemic stroke. The outcomes and safety profile are similar to those of patients with no prior anticoagulation therapy.

¿Guardia específica de ictus?. Réplica / A specific on-call stroke service? Reply

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